Opioids might also cause worsening of pre-present central slumber apnoea (see segment 4.8). Concomitant usage of oxycodone and sedative medicines for instance benzodiazepines or relevant medication may possibly lead to sedation, respiratory depression, coma and Dying. As a result of these hazards, concomitant prescribing with these sedative medicin

German chemist Albert Niemen outlying copyright, an important drug from your coca leaves. Researchers conduct it during the 1860s. He tasted this white crystal powder and afterwards observed that his tongue became senseless. An additional researcher, Angelo Mariani, a French chemist, would make a tonic from Bordeaux wine and coca leaves. copyrig